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Messages - Ageless the Drifter

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General Discussion / test tube vaginas
« on: April 11, 2014, 10:49:10 AM »

Doctors implant lab-grown vagina

Four women have had new vaginas grown in the laboratory and implanted by doctors in the US.

A tissue sample and a biodegradable scaffold were used to grow vaginas in the right size and shape for each woman as well as being a tissue match.

They all reported normal levels of "desire, arousal, lubrication, orgasm, satisfaction" and painless intercourse.

Experts said the study, published in the Lancet, was the latest example of the power of regenerative medicine.
'I feel fortunate'

In each woman the vagina did not form properly while they were still inside their mother's womb, a condition known as vaginal aplasia.

Current treatments can involve surgically creating a cavity, which is then lined with skin grafts or parts of the intestine.
Scaffold The scaffold is made of a biodegradable material

Doctors at Wake Forest Baptist Medical Centre in North Carolina used pioneering technology to build vaginas for the four women who were all in their teenage years at the time.

Scans of the pelvic region were used to design a tube like 3D-scaffold for each patient.

This is an exciting glimpse into the future of medicine. Using living tissue as building material to transform the lives of patients has already happened with bladders, blood vessels and windpipes. Now you can add vaginas and noses to the list.

There are even attempts to make more complex organs. Weakly beating hearts and kidneys that can produce urine have been made in animal studies. But this is still a long way from being used in humans.

Expect 3D printing to revolutionise this field as the technology to precisely place both the cells and the scaffolding improves.

Muscle cells were attached to the outside of the scaffold and vaginal-lining cells to the inside.

The vaginas were carefully grown in a bioreactor until they were suitable to be surgically implanted into the patients.

One of the women with an implanted vagina, who wished to keep her name anonymous, said: "I believe in the beginning when you find out you feel different.

"I mean while you are living the process, you are seeing the possibilities you have and all the changes you'll go through.

"Truly I feel very fortunate because I have a normal life, completely normal."
'An important thing'

All the women reported normal sexual function.

Vaginal aplasia can lead to other abnormalities in the reproductive organs, but in two of the women the vagina was connected to the uterus.

There have been no pregnancies, but for those women it is theoretically possible.
Scaffold in an incubator The scaffold is placed in an incubator

Dr Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest, told the BBC News website: "Really for the first time we've created a whole organ that was never there to start with, it was a challenge."

He said a functioning vagina was a "very important thing" for these women's lives and witnessing the difference it made to them "was very rewarding to see".

This is the first time the results have been reported. However, the first implants took place eight years ago.
'Most important questions'

Meanwhile, researchers at the University of Basel in Switzerland have used similar techniques to reconstruct the noses of patients after skin cancer.
Scientist in lab The other side of the scaffold is coated with smooth muscle cells before it is incubated a second time

It could replace the need to take cartilage from the ribs or ears in order to rebuild the damage caused by cutting the cancer away.

Prof Martin Birchall, who has worked on lab-grown windpipes, commented: "These authors have not only successfully treated several patients with a difficult clinical problem, but addressed some of the most important questions facing translation of tissue engineering technologies.

The steps between first-in-human experiences such as those reported here and their use in routine clinical care remain many, including larger trials with long-term follow-up, the development of clinical grade processing, scale-out, and commercialisation."

General Discussion / Re: Back in my day, we had to fight to be nerdy
« on: April 11, 2014, 10:45:25 AM »
Big Ageless did you know that Talisman is now on steam? I ordered the physical board game a couple weeks ago and I am awaiting the ship date with all the expansions but in the interim we could nerd out hard on some E-talisman

Spamalot / Re: kill your friend sors
« on: April 11, 2014, 12:52:47 AM »
If I drew an orbital plot of the rotation of the sun (or the earth or anything really) relative to my finger it would show the sun orbiting my finger.

I missed this part at first  :huh: :huh: :huh:

Spamalot / Re: kill your friend sors
« on: April 11, 2014, 12:47:37 AM »
Throw out gravity throw out any semblance of actually what is moving and just look at this from the point of view of what was asked to the respondents. They asked does the earth revolve around the sun. Not orbit, not move. It's akin to a saying tree shadow revolving around its trunk.


General Discussion / Re: Back in my day, we had to fight to be nerdy
« on: April 11, 2014, 12:07:44 AM »
Portlandia - Nerd PSA

Spamalot / Re: yase
« on: April 10, 2014, 11:15:41 PM »

you're always thinkin of me

Spamalot / Re: Last Week Of Your Life
« on: April 09, 2014, 04:04:34 PM »
I've never done acid specifically but I've tripped

the molly thing probably wouldn't work out though, you're right

a man can dream, can't he?

the thought of getting stabbed definitely makes me cringe a lot harder than the thought of getting shot

which is not to say it wouldn't still be preferable by any rational standard

General Discussion / Re: K-12 Japanese Immersion
« on: April 09, 2014, 03:56:47 PM »
also that's p baller Vlaara, grats

super jealous I didn't get to do some shit like that--not even because it's Japanese but just because polyglotism

General Discussion / Re: K-12 Japanese Immersion
« on: April 09, 2014, 03:55:30 PM »
hey taket, maybe your parents should have put you in an english emersion program. lmao


Spamalot / Re: Last Week Of Your Life
« on: April 09, 2014, 03:51:41 PM »
molly and acid the entire time

Spamalot / Re: lol
« on: April 07, 2014, 08:32:51 PM »
If that's not what you're saying then I apologize.

Nope, just saying that having directed one movie I really enjoyed--if in part for the directing, admittedly--for many reasons besides the directing is not going to make me fawn over a director. Basically just saying that I personally am pretty meh on Aronofsky as a direct response to Ziakas' assertion that I'm a fanboy of his.

Spamalot / Re: lol
« on: April 07, 2014, 07:08:52 PM »
Knew I was forgetting one. The Wrestler was a very good movie, I agree.

I'm not trying to *discredit* Aronofsky, I'm just giving my opinion. I think he's above average (maybe great? I don't care enough to consider it) he's just not someone I spooge over as a matter of taste. The directing of Requiem was a non-trivial component of its success, absolutely no doubt about it. But there's a reason Pi wasn't as successful, and it's not anything wrong with Pi so much as it's all the stuff besides the directing that Requiem got hella right.

Spamalot / Re: lol
« on: April 07, 2014, 01:17:17 PM »
I don't even really like Aronofsky--not especially, anyway. Black Swan was alright and I thought Requiem was really good (let's be honest though--half that movie's success was the score). Pi was...alright. But I'd seen Requiem first and the directing is too similar not to be distracted by the similarity. The Fountain was not my thing at all.

I wasn't sure how to feel about this movie. It looked dumb in the trailers but sometimes that shit'll surprise you, especially when it's a story like this one where you hear the title and immediately make assumptions about it. I like Russel Crowe but I feel like his presence in a movie says little about the quality of the script. Same with Emma Watson but only because I've only seen her in one thing outside of Harry Potter.


General Discussion / Re: Shrek is love, Shrek is life
« on: April 03, 2014, 12:33:38 PM »
wwhy shrek is piss

General Discussion / Re: Seriously bad news for our beloved country
« on: April 03, 2014, 05:40:07 AM »
Gerrymandering is still such a relevant thing. I feel like if images of the most egregiously gerrymandered congressional districts floated around the internet with dumb captions just so people recognized that it was still a thing it could singlehandedly alter the course of major elections

General Discussion / Re: Seriously bad news for our beloved country
« on: April 03, 2014, 05:36:53 AM »

Spamalot / Re: Hot girls in porn
« on: April 03, 2014, 05:25:56 AM »
Parking Fail


Even worse, you have to suppose that was going on for quite a while to make someone think it would be worth filming and bust out the camera

General Discussion / Re: Comments for RL Pic Posts - 2014 Thread
« on: April 02, 2014, 02:02:21 PM »
Funny, there's a World of Beer on the University in the city I live in as well

General Discussion / Re: foxnews.jpg
« on: April 01, 2014, 04:18:27 PM »
I signed up whatever day it was that I posted in that spamalot thread asking if that day was the deadline. Was like a week ago or less. Site was working great by then--just asked me a bunch of super easy financial questions and shit and then showed me a list of plans with my tax break already included in the price. Got catastrophe insurance completely free, no longer have to worry about tax penalty. Whole thing took 20 min.

Spamalot / aw yiss
« on: March 30, 2014, 09:09:54 PM »
new Rick and Morty episodes

General Discussion / Re: I ate the waffle taco
« on: March 30, 2014, 08:34:46 PM »
Also that gif is endlessly amusing

Sent from my SM-N900V using Tapatalk

the loop is masterful

Sors this is a great early birthday present

I'm v lucky Euler seems to have no inclination to get fat whatsoever. She just wants to play fetch all day and often won't even finish her second bowl of dogfood for the day.

you can't imagine the man hours that go into CGI that polished

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