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Messages - Ageless the Drifter

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31
my thesis was about eigenvectors of graph laplacians

32
General Discussion / Re: Promising alzheimer's treatment
« on: March 19, 2015, 02:50:41 PM »
Yeah that's what I'm saying. I'm sure there are plenty of people that'd take a 30/70 on stroke/alzheimer's relief over certainty of continued loss of faculty until demise

33
General Discussion / Promising alzheimer's treatment
« on: March 19, 2015, 02:04:36 PM »
http://www.sciencealert.com/new-alzheimer-s-treatment-fully-restores-memory-function




New Alzheimer’s treatment fully restores memory function

Of the mice that received the treatment, 75 percent got their memories back.
BEC CREW
18 MAR 2015
Facebook Icon11.kTwitter Icon1.4kEmail Icon
 

Australian researchers have come up with a non-invasive ultrasound technology that clears the brain of neurotoxic amyloid plaques - structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients.

If a person has Alzheimer’s disease, it’s usually the result of a build-up of two types of lesions - amyloid plaques, and neurofibrillary tangles. Amyloid plaques sit between the neurons and end up as dense clusters of beta-amyloid molecules, a sticky type of protein that clumps together and forms plaques.

Neurofibrillary tangles are found inside the neurons of the brain, and they’re caused by defective tau proteins that clump up into a thick, insoluble mass. This causes tiny filaments called microtubules to get all twisted, which disrupts the transportation of essential materials such as nutrients and organelles along them, just like when you twist up the vacuum cleaner tube.

As we don’t have any kind of vaccine or preventative measure for Alzheimer’s - a disease that affects 343,000 people in Australia, and 50 million worldwide - it’s been a race to figure out how best to treat it, starting with how to clear the build-up of defective beta-amyloid and tau proteins from a patient’s brain. Now a team from the Queensland Brain Institute (QBI) at the University of Queensland have come up with a pretty promising solution for removing the former.

Publishing in Science Translational Medicine, the team describes the technique as using a particular type of ultrasound called a focused therapeutic ultrasound, which non-invasively beams sound waves into the brain tissue.  By oscillating super-fast, these sound waves are able to gently open up the blood-brain barrier, which is a layer that protects the brain against bacteria, and stimulate the brain’s microglial cells to move in. Microglila cells are basically waste-removal cells, so once they get past the blood-brain barrier, they’re able to clear out the toxic beta-amyloid clumps before the blood-brain barrier is restored within a few hours.

The team reports fully restoring the memories of 75 percent of the mice they tested it on, with zero damage to the surrounding brain tissue. They found that the treated mice displayed improved performance in three memory tasks - a maze, a test to get them to recognise new objects, and one to get them to remember the places they should avoid.

"We’re extremely excited by this innovation of treating Alzheimer’s without using drug therapeutics," one of the team, Jürgen Götz, said in a press release. "The word ‘breakthrough’ is often misused, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach."

The team says they’re planning on starting trials with higher animal models, such as sheep, and hope to get their human trials underway in 2017.

You can hear an ABC radio interview with the team here.



I feel like they really ought to be able to just start human trials on a volunteer basis when promising possible new treatment for something as rapidly and devastatingly degenerative as alzheimer's. I mean, obviously they'd have to screen pretty thoroughly to make sure all the volunteers are of sound enough mind to consent, but I can't imagine there'd be any shortage of such people. What's the worst that could happen for that person? If they have to wait two years there's a good chance that their brain will be at least as fucked up from the passing time as it would've been from the side-effects of the experiment if there turn out to be any.

34
General Discussion / Re: oh lawd old ppl rpg memories
« on: March 18, 2015, 01:40:49 PM »
they don't matter much to me, at least in determining my opinion of the game overall. Most of my favorite games have those crappy 3d old graphics. I've never gone back to play Zelda OoT and wished it looked different.

But if we *are* talking about graphics there's just no two ways about it--some of the later 2d sprite games were visual fucking masterpieces (DK Country, Mario RPG) and still look great today. Of course, graphic artists had been working with those graphical limitations (or worse) for quite a while by that time. I wonder, if game artists had been forced to work with 64bits for another decade whether they would have eventually come out with a crappy-3d-engine style that worked as well within those limitations as those later 2d games did within theirs.

I almost wish we'd've gotten to find out--so many games now have practically unending graphical resources and do nothing at all interesting with them.


35
General Discussion / Re: John Quiggin Thinks the TPP Sucks
« on: March 18, 2015, 12:50:32 PM »
It seems like I've been hearing about this too little for too long for there to be any realistic hope of a movement against it having any success against its current momentum.  :sad:

36
Spamalot / Re: bitch
« on: March 17, 2015, 05:25:24 PM »
:giggle:

37
Spamalot / Re: They say it takes 10,000 posts
« on: March 17, 2015, 04:43:39 PM »
Yeah but it doesn't hurt

38
General Discussion / Re: oh lawd old ppl rpg memories
« on: March 17, 2015, 03:39:10 PM »
I'm a sucker for early (or any, really) N64 games

But yeah 2d sprites age better than bad 3d

39
I always felt like the bad trip experience could stick with you long after the effects wear off.

I think that's true if only in the sense that having anything traumatic happen to you can have a lingering effect.

40
Spamalot / Re: KILL UTUMNO
« on: March 16, 2015, 10:38:37 PM »

41
Spamalot / Re: Am I a terrible 33 year old?
« on: March 16, 2015, 04:06:33 PM »
I'm not very familiar with Tay Swift but I'd still echo the last half of what Klerick said

Hell I'd go as far as to say you might be a bad 33 y/o if your masculinity or w/e wouldn't allow you to like Tay Swift

42
Spamalot / Re: KILL UTUMNO
« on: March 16, 2015, 04:04:14 PM »
Ageless is poor and lives within his means. And likes it (or has at least convinced himself he likes it).

-tapatalk


I mean I wouldn't turn down more money for nothing but I like my relative leisure more than I appreciate the difference between cheap food and food I'd have to get a better job to afford regularly and still be able to travel/go to shows and that sort of thing

+we make food at home most of the time

43
Spamalot / Re: KILL UTUMNO
« on: March 16, 2015, 12:27:47 PM »
I'll eat the fuck out of some Cici's as well

44
Spamalot / Re: KILL UTUMNO
« on: March 15, 2015, 10:52:14 PM »
Lil Cease ain't great but for being able to walk in, slap a $5 on the counter and walk out with a hot pizza ten seconds later I'll take it

45
The way I see psychadelics is this:

In optimization problems there's a process called "hill climbing."  The idea is that you can imagine all possible solutions being arranged in some way to create a "state space," and each point in the state space has a value according to whatever you're trying to optimize, which you can illustrate with separate axis, like in this picture:



So a hill climb is when you just pick any random point in the state space, and then you check each of its neighbors to see if they sit higher on the y axis than the point you're at. if not, stay put; otherwise, move to the point that's higher. Rinse and repeat.

But the problem is that if you stared out in the valley between (b) and (c) in the image above, then this hill climb process could only ever take you as high as either (b) or (c), because once you hit a peak, every point in your neighborhood is lower than where you are. Since (a) is clearly where you actually want to be, this is no good.

So to avoid getting stuck like this, you can use what's called "simulated annealing," which is basically where, if your solution's at a peak, you rattle it off the peak to a random point nearby to see if it lands on the side of another, taller hill.

When I think of psychadelics, I imagine the human mind as wandering in a state space where the solutions are ways of seeing the world, and the value of the solution is how well that world-view describes your experiences.

Minds tend to hill-climb and then get stuck. The value of psychadelics is that they rattle minds off local maxima and offer the opportunity to find a higher hill to climb (although your initial landing point may be lower than the peak you were rattled off of). The hazard is that you could of course land on the slope of a hill whose peak is lower. Or, if you just keep taking psychadelics all the time, it doesn't matter what peaks you visit because you're always being knocked off of them and, since peaks constitute a relatively small subset of the overall landscape, on average, you're going to spend a lot of time in valleys.

46
General Discussion / Re: Which game is better, WOW or EVERQUEST?
« on: March 15, 2015, 12:44:38 PM »
or did I

47
General Discussion / Re: Which game is better, WOW or EVERQUEST?
« on: March 15, 2015, 12:44:24 PM »
I voted for WoW

49
In global terms we're all a part of the 1%.

This is good perspective to have of course but I feel like the only people I ever hear throwing this out (present company excepted) are people who are trying to write off Occupy, which is odd. Like, yeah okay, we are the 1% but then the so-called 1% is the .00001% or something and they still control a disgusting amount of the world's resources. I feel like the natural conclusion to draw from that should be to say fuck them even harder rather than "oh, guess it's not worth talking about then"

50
To no one's great surprise




http://www.forbes.com/sites/stevenkotler/2015/03/11/are-psychedelics-the-wonder-drug-weve-been-waiting-for/2/

The idea that psychedelics cause psychosis has a long history in urban mythology. Back in the 1980s, when I was a teenager, the way I heard the story was “seven hits of acid make you legally insane.”

Of course, the number fluctuated through the years, but the core idea—drugs like LSD and psilocybin are dangerous to our long term mental health—remained a constant.

Until now.

Two new studies have found no link between psychedelic use and a wide suite of mental health conditions, including schizophrenia, psychosis, depression, anxiety disorders and suicide attempts.

The first, conducted by researchers from the Norwegian University of Science, made use of the copious data compiled by US National Survey of Drug Use and Health. By examining answers from 135,000 people who took the survey between 2008 and 2011, the researchers identified their core study group—the 14 percent of survey-takers who said they had used any of the three classic psychedelics (acid, mushrooms, or peyote) at some point in their lives.

Working backwards, they discovered that psychedelic-users were not at an increased risk of developing eleven key indicators of serious mental health problems.

A second study done at Johns Hopkins confirmed this finding. This study used the National Survey as core data, but examined responses from 2008 to 2012. Here too, the researchers involved also found no causal relationship between the three classic psychedelics and long-term mental health problems.

But where this second study gets even more interesting is that the researchers then inverted their line of questioning and went looking for positive mental health developments. And they found them. People who had tried LSD or psilocybin had lower lifetime rates of suicidal thoughts and attempts.

Of course, this isn’t the first positive mental health outcome to be attributed to these drugs. The research into psychedelics as a treatment for end-of-life anxiety (brought on by terminal illness) shows that these substances are effective in treating severe anxiety and—equally important—that these benefits persist over time.

Meanwhile, researchers at the Imperial College in London have also begun peeling back the veil on the so-called ‘mind-expanding’ nature of psychedelics, finding some serious scientific evidence for reasons why these drugs help users release longstanding narrow-minded, negative outlooks.

And, finally, there’s also a bevy of research dating back to the 1950s that shows strong correlations between psychedelics and enhanced creativity. This research helps explain why Steve Jobs said taking LSD was one of the most important things he’s done in his lifetime, why Francis Crick was high on low-dose acid when he discovered the double-helix and why Tim Ferriss, in a recent interview with CNN, said: “”The billionaires I know, almost without exception, use hallucinogens on a regular basis. [They're] trying to be very disruptive and look at the problems in the world … and ask completely new questions.”

But the larger point is that one in five adult Americans takes some kind of mental health drug—meaning anti-anxiety, anti-depressant, anti-psychotic, etc. What’s more, success rates are suspect. Only 15 percent of people treated for depression with drugs, for example, show long term remission.

But psychedelics—a class of long-vilified substances—are not only much safer than we believed (i.e. they don’t appear to make you crazy) and also shows significant long term mental health benefits across multiple categories: anti-depressant, anti-anxiety and performance-enhancement (for creativity). What’s more, to receive these benefits, you only need to take these substances a few times (not every day like other mental health medications).

Tim Leary believed psychedelics were tools for revolution—tune in, turn on, drop out, and all that. Well, perhaps.

But lost in all that buster is a much more prosaic yet powerful message—the real truth might be that these drugs can help us be a little less afraid and a little bit happier and isn’t that revolution enough?




I'd still like to see a metastudy investigating the link between frequent psychadelic use and believing that, like, money is just like, fluid, ya know? though.

51
General Discussion / Re: Happy Pi day TZT
« on: March 14, 2015, 06:42:15 PM »
e is the greatest constant in math

52
I think that's called the free-rider problem in game theory (also read: why humans can't have nice things)

54
General Discussion / Terry Pratchet down
« on: March 12, 2015, 12:47:31 PM »
surprised out of all you nerds no one cared enough to post about it

I never read anything by him tho

55
Spamalot / Re: Former boss's daughter kidnapped
« on: March 12, 2015, 12:28:11 PM »
that just seems...fake. i know it very well might not be, but it just seems so odd that someone would be posting updates on their kidnapped daughter via facebook.

~

That was my thought as well.

Here's hoping she kidnapped herself

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General Discussion / Re: soooo many adbars with frowny-face obama.
« on: March 12, 2015, 12:24:42 AM »
 :smitten:

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General Discussion / Re: soooo many adbars with frowny-face obama.
« on: March 11, 2015, 04:05:56 PM »
Earl Sinclair performs Hypnotize by The Notorious B.I.G.

58
Spamalot / Re: Condescending Self-Help Lambo Guy
« on: March 09, 2015, 02:49:41 PM »
pls find that and repost it sometime  :smitten:


haha, I forgot about that. Was it this one?

Been Far?

59
Spamalot / Re: Condescending Self-Help Lambo Guy
« on: March 07, 2015, 08:03:26 PM »



this must be acknowledged. i enjoyed it.


tyvm I thought I was going to wind up being the only person who thought it was funny

60
General Discussion / Re: Yep, I'm very close to quitting my job
« on: March 07, 2015, 02:39:14 AM »
Looks like you dont have to quit your job mr tulion


Edit- god damn cell phone http://news.yahoo.com/3-officers-la-skid-row-death-had-training-081702655.html


Why do you care its just another dead nigger to you?
this guy was a real piece of shit. good riddens.


Riddance

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