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Messages - Shoelayceberry the [Unlaced]

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Tech Heads / Re: CA infrastructure and and usage
« on: Today at 01:06:27 PM »
 ;) fair enough

I just haven't done anything with NoSQL to understand it and it's uses. The first use case I ran across that made sense to me was for document management, like Xerox DocuShare or MS Sharepoint - and recently as a solution for AWS, which, of course, Chemosh reminded me of.

Anyway, anything to add to help me understand Certs?

General Discussion / Re: More Brain Zaps for Learning/Memory
« on: May 24, 2015, 05:27:10 PM »
I'll take 2 zaps and glazed donut - to go.

Tech Heads / Re: CA infrastructure and and usage
« on: May 24, 2015, 04:26:09 PM »
the only ref to NoSQL that I have run across is as a document management scenario.

Tech Heads / Re: CA infrastructure and and usage
« on: May 24, 2015, 03:40:25 PM »
Upload to nosql db, poll it daily and email if cert is one month from expiring. Can also publish to some kind of dash board

Like make a copy elsewhere, then do a daily scripted check of some kind? There isn't some built-in better MS way?

Tech Heads / CA infrastructure and and usage
« on: May 24, 2015, 01:27:37 PM »
Cisco LIVE 2015 in 2 weeks, so still studying to re-certify. The next thing I need to feel confident on is Certificates. This is one of those topics I understand while being taught, but quickly forget as I go about my other work. After a good network design, and DNS implementation, I think certs are rapidly becoming the next most important topic for admins to understand above all else, fueled by flight to the public cloud, if nothing else.

We have our own internal CA and I am scared to deal with it. What are some good videos or readings I can do to feel more confident? Also, what are good methods for tracking expiration of your internal certs?

General Discussion / Re: Odd ways to die
« on: May 20, 2015, 01:12:13 PM »
love me some ilfscience

Spamalot / Re: someone got fired today
« on: May 19, 2015, 07:54:35 PM »
Cool. Watch yer corn hole buddy.

General Discussion / Re: Art people + technophiles: Tablet shopping
« on: May 19, 2015, 04:28:52 PM »
good luck

Spamalot / Re: someone got fired today
« on: May 19, 2015, 03:18:53 PM »
Aro, was this for the Forestry job?

cyberball + might & magic!

genesis rocked. lots of rpgs

Vegamance = Vaeden right? If so, Dr Vae, MD monthly poster
Thurloc pops in rarely these days, every 6 months or so
Zebb/Keamina disappeared a few years ago now
Astitious/Celestine Asti pops by a bit, on the order of every year, maybe a bit more
Gylen same
Rulan disappeared many years ago now

No.  MSE is almost but not quite useless at actual protection.  I feel ashamed for relying on it for my personal computer to be honest.  I would never entrust it to protect a business.

I'm a Symantec admin at my job. See if you can reduce costs with Small Business Server, or try non-managed. The product is fine. You'll find rabid fans of other tech. Use whichever works best for you. Relying on a installed virus scanner that doesn't do anything else is a bad move. Relying on any antivirus product alone is not enough anymore. Layers, layers, layers...

Spamalot / Re: puked a little blood yesterday
« on: May 12, 2015, 05:20:34 PM »
a natural home remedy I like to use is the McRib Cleanse

flush the toxins from ur body by flooding it with McRibs and Diet Dr Pepper

50% of the time, it works every time.

I'm on the list for a Tesla SUV and am building a house that is going to incorporate the powerwall.

I'm a huge fan of what he's doing. 

Awesome. What will be your use case? Fully off-grid, Emergency backup, usage leveling, none of the above?

Spamalot / Re: For those of you with fear of heights
« on: May 11, 2015, 04:52:18 PM »
fuck that shit

General Discussion / Re: Etok down
« on: May 11, 2015, 03:54:34 PM »
I remember reading something from Greg Palast as well:

There is a legend told among the Inupiat Alaskans who live above the Arctic Circle, “Etok Tames the Green People.” It goes like this:

In the Old Days, as today, the peoples on the edge of the Arctic Sea killed whales. It’s just what they do. It’s what they eat. But the Green People didn’t like that, and so the Green People set out one day in their fancy-ass black powerboat to stop the people of the Arctic Sea from doing their whale killing thing.

It was a long, long time ago in 1979. The elders tell us how the Green People showed up outside the Inupiat Native village of Kaktovik in their black powerboat and set out their stores of vegetables on the beach. The Green People only ate green food. The Green People then set off in their black powerboat on their blubber-saving mission, with a plan to block the Eskimo’s bidarka whaling ship. Quick as a Raven’s wink, they got lost in a fog bank and stuck in the ice sheet. Prepared, committed, and resourceful, the Green People set out their pup tents on the ice floe and slept, hoping for the fog to lift in the morning.

But they were not lost. The Inupiat of the Arctic Sea knew exactly where the Green People were. Etok, the great whale hunter, told his villagers to accept the gift of the Green People and take all their vegetables. Etok then told his people to be patient, and, elders say, they lit up some excellent weed, put on Bob Dylan tapes, and waited.

During the summer the sun never sets in the Inupiat land. It just rolls around the sky in a Circle. And under the gyrating sun, the Greens’ expensive boat, being black, absorbed the radiant heat, melted the ice holding it and drifted out into the endless Sea.

By three a.m., the wait was over, and the patient Eskimo leader told his people to go and retrieve the lost black boat, call the Coast Guard, and claim it as abandoned property.

In the morning, the Green People awoke, still in fog, and did not see their boat, their boat with their emergency radio and food. The Green People drifted on their block of ice, lost and doomed. Etok told his people not to move, that the Green People must “cry themselves out” and obtain the wisdom that comes with accepting your certain death by starvation, hypothermia, or polar bear.

The Inupiat of the Arctic Sea waited an entire day. Then another day and another day.

On the fourth day, Etok figured the Green People were now wise enough, hungry enough, and thirsty enough. He ordered his people to rescue them. “They are vegetarians,” the wise Etok explained to his people and ordered them to bring many buckets of mikiaq, fermented whale meat in congealed blood. The hungry Green People ate the whale, no longer giving a shit that it was some goddamned endangered species. The Inupiat told them it was not wise to enter the Native boats. The rescue party had brought along a filthy crude-oil barge for the frozen Green People to ride.

The Natives dumped the Green People at Dead Horse, where White People take petroleum from Prudhoe Bay. The Green People, whose lesson had been taught to them without their knowing, thanked the Inupiat for saving their lives. And from that day forward, Greenpeace protected the Natives’ right to kill whales as in the Old Days, and joined the Inupiat people in fighting their competitors, the commercial whalers or, as the Natives call them, “the fucking Japanese.”

Etok is one bad-ass Eskimo.

awesome. thanks.

General Discussion / Re: universal to open a nintendo theme park
« on: May 09, 2015, 11:55:33 PM »

I wrote a long ass post when this was originally posted, including # of sunny days in San Diego and higher average wages, but then had to reboot and lost it. Basically, this isn't very expensive at all, for SoCal people, though the non-inclusion of the other pieces you need to make this work, other than as an awesome paperweight, is a bit of misdirection. I will say that I called my wife over and made her watch the youtube of the announcement saying that it was one of those pivotal moments that people will remember for a long time.

Attached is my energy use for most of the year. The last 2 summer - and probably this one coming up - have been brutal, so it's about 70% higher then.

General Discussion / Re: Resistance documentary
« on: May 05, 2015, 04:00:38 PM »

Scientists have designed a new class of antibiotic which seeks and destroys resistance genes in bacteria.

The unique approach could be used to genetically engineer bacteria in our bodies to become less dangerous.

The technology might also lead to new treatments for metabolic diseases like obesity, the researchers claim.

Scientists and politicians have warned that we face a return to the medical "dark ages" if action is not taken against antibiotic resistance.

The human body houses ten times more bacterial cells than human ones. This community of bacteria is termed the microbiome and its importance in keeping us healthy is increasingly recognised.

One of the problems with current antibiotics is "they hit not only the bad bacteria but also the good bacteria," explained Professor Timothy Lu of the Synthetic Biology Center at Massachusetts Institute of Technology, who led the team carrying out the new research.

"It allows the bad bacteria to flourish."

In a series of laboratory experiments published in Nature Biotechnology, the researchers showed they could produce a molecular "conditional-lethality device" capable of highly targeted action against the "bad" bacteria in a consortium of different strains.

The new antibiotic uses an RNA-guided nuclease called a "Crispr" to hunt down and chop up target genes inside bacterial cells.

"We designed Crispr systems that would go into bacteria and specifically kill only bacteria that contain antibiotic resistance genes or virulence genes," explained Professor Lu.

The bacteria targeted in the experiments included a strain of E. coli which can cause severe diarrhoea and kidney failure.

But Professor Lu isn't only interested in killing the deadly bacterium - he wants to rehabilitate it.

In separate experiments the researchers showed they could change the genetic makeup of bacteria without killing them.

"Inherently E. coli is not necessarily a bad organism," Professor Lu explained. "They carry genes that make them bad."

Targeting the bad genes, instead of killing the good and bad bacteria alike, is a new approach which "imposes direct evolutionary pressure at the gene level".

Professor Lu is confident the new antibiotics could be ready for clinical trials in some infections "within a few years."
Resistance is futile?

No new classes of antibiotic have been developed for more than 25 years.

The overuse of available antibiotics favours the survival of bacteria resistant to the drugs. These bacteria can then transmit their resistance genes to other bacteria using tiny circles of DNA called plasmids.

The process effectively speeds up evolution to produce bugs that cannot be killed when they cause disease.

The problem is huge and attracted the attention of Prime Minister David Cameron in July, when he announced a new interdisciplinary panel to address the issue.

"If we fail to act, we are looking at an almost unthinkable scenario where antibiotics no longer work and we are cast back into the dark ages of medicine where treatable infections and injuries will kill once again," he said.

Professor Lu described the problem as "a technological arms race between us and the bacteria".

The new system is "a new type of antimicrobial that really acts very differently to previous ones, and I think that's why we're particularly excited about it," he explained.

The technology could eventually be given to healthy people to prevent antibiotic resistance developing.

"You might take probiotic bacteria while you are healthy, and that probiotic bacteria could distribute these Crispr constructs into your natural bacterial population, and kind of immunise them from being able to pick up bacterial resistance genes.

"So just like the antibiotic resistance plasmids naturally spread in a population, we could potentially design these Crispr constructs to also spread… like a parasite that hops from bacteria to bacteria."

"Think about it like a vaccine - but it's a vaccine for your bacteria, not for you."

Introducing self-replicating gene treatments into the microbiome would not be without risk.

"This is admittedly a little bit radical but I think it's an interesting thing to consider."
'An enabling toolkit'

"The use of antimicrobial agents based on DNA has exciting potential that has not yet been effectively harnessed," said Lucinda Hall, professor of molecular microbiology at Queen Mary University of London.

"The greatest challenge is how to deliver a DNA-based agent into the bacteria to be targeted."

The MIT team explored two approaches to this.

"One idea is that you can just piggy back off the same system that bacteria use to trade resistance genes," Professor Lu explained. In this approach the target cell accepts a 'Trojan horse' plasmid of DNA from another bacteria, with the Crispr hidden inside.

But this would require live bacteria to be given to a patient - so "it is probably not the best solution for an acute infection," he conceded.

Secondly, the team used bacteriophages - natural virus predators of bacteria which are highly adept at injecting DNA into host cells.

This approach is also not without difficulties. "You have to find the right type of phage to bind to each type of bacteria," explained Professor Hall. "There is also a question about how easily phage can reach the site in the body where the bacteria are causing an infection, and whether they will be blocked by antibodies."

"It is something we have to take into consideration," responded Professor Lu. "Other groups have found pretty interesting ways around this, for example coating the bacteriophages with chemicals that basically shield them from the immune system."

Professor Hall was also critical of the bacterial kill rates reported, describing the numbers as "disappointing".

"We need to continue to improve the efficacy," conceded Professor Lu. "But even with [relatively modest] drops in bacterial count you can detect significantly increased survival of the waxworms we were using for testing."

The benefits of manipulating the balance of "good" and "bad" bacteria in the body might extend beyond fighting infection.

"There are certain classes of bacteria in your gut that are known to be overrepresented in people who are obese or have metabolic diseases," explained Professor Lu.

"We could design Crispr-based systems that would go into bacteria, targeted to certain subsets of bacteria, and only activate when they recognise genes that we know are correlated with human disease."

"This is an enabling toolkit for the basic scientists to now start probing these systems a little bit better."

Spamalot / Re: All TZT's young people
« on: May 04, 2015, 11:44:39 PM »
and the rest of you fogeys are in bed by 8PM PST anyway


General Discussion / Re: EndNote
« on: May 01, 2015, 02:40:18 PM »
A lot of the younger researchers here use it. I really had no idea and was assuming/hoping it was an open/free Endnote replacement.

Getting Fat with TZT / Re: Dear Everyone (Mostly Xanon)
« on: May 01, 2015, 02:37:50 PM »

(I didn't ask for anything)

General Discussion / Re: EndNote
« on: April 30, 2015, 11:10:16 PM »
Check this out:

but see above about collaborations.

General Discussion / Re: EndNote
« on: April 30, 2015, 11:08:48 PM »
Because EndNote is a fucking racket, that's why, but like Photoshop, you HAVE to fucking use it because everyone else does and of you collaborate you have to all use the same fucking format.

Fuck EndNote.

It's also tied to your version of MS Office, so you can upgrade/patch yourself out of compatibility and have to re-buy it.

Fuck EndNote.

General Discussion / Re: Comcast pulls bid for Time Warner Cable
« on: April 30, 2015, 11:52:52 AM »
Started messaging some of my old work colleagues at Charter about this yesterday. There was a TON of work done by my old group as far as positioning the network for this deal and the areas that would be swapped with Comcast, all of which would become worthless, and a lot of work needing to be done to reverse some of the things already done. I'm laughing at them, and they are not too happy right now, lol.

lol pwned

Tech Heads / Re: Windows Just Crapped Itself
« on: April 29, 2015, 02:19:19 PM »
You can buy really cheap - less than $15 - PSU testers. I've never used one, but bought one recently for my own, possible, PSU issue. There are also many software tools to test hard drives - look into Hiren's Boot Disk, you one stop shop.

General Discussion / Re: Some should f! fry for making this legal.
« on: April 27, 2015, 02:32:04 PM »
that's like saying 'oh this basketball rim we're letting you throw in for prizes has a randomized chance of just closing the second you release the ball' and people being ok with it. People know the balls are a little wonky (over or underinflated), the rim is bent a lil, and it's a bad angle, but they'd be losing their minds if you just said 'fuck you, random dice-roll says you physically cannot win on this throw'.

Big Liz should get on this shit


I wouldn't be surprised at all if carnies could manipulate outcomes on at least some of the games in real time.  Manipulate angles/distances so you pay out when there's a crowd.

they are rigged from the beginning to be very low percentage winnable with cheap prizes.

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